Detalhe da pesquisa
1.
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Cell
; 186(4): 786-802.e28, 2023 02 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36754049
2.
p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR).
Cell
; 184(3): 689-708.e20, 2021 02 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33482083
3.
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules.
Cell
; 172(3): 590-604.e13, 2018 01 25.
Artigo
Inglês
| MEDLINE | ID: mdl-29373831
4.
Rethinking Unconventional Translation in Neurodegeneration.
Cell
; 171(5): 994-1000, 2017 Nov 16.
Artigo
Inglês
| MEDLINE | ID: mdl-29149615
5.
Ribosome profiling reveals novel regulation of C9ORF72 GGGGCC repeat-containing RNA translation.
RNA
; 28(2): 123-138, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34848561
6.
The exocyst complex in neurological disorders.
Hum Genet
; 142(8): 1263-1270, 2023 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-37085629
7.
Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD.
Proc Natl Acad Sci U S A
; 116(19): 9628-9633, 2019 05 07.
Artigo
Inglês
| MEDLINE | ID: mdl-31019093
8.
Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder.
EMBO J
; 36(20): 2931-2950, 2017 10 16.
Artigo
Inglês
| MEDLINE | ID: mdl-28916614
9.
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport.
Nature
; 525(7567): 129-33, 2015 Sep 03.
Artigo
Inglês
| MEDLINE | ID: mdl-26308899
10.
Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation.
Mol Cell
; 52(2): 264-71, 2013 Oct 24.
Artigo
Inglês
| MEDLINE | ID: mdl-24095276
11.
The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia.
Hum Mol Genet
; 27(8): 1382-1395, 2018 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29432529
12.
ALS-linked protein disulfide isomerase variants cause motor dysfunction.
EMBO J
; 35(8): 845-65, 2016 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26869642
13.
A Drosophila model of ALS reveals a partial loss of function of causative human PFN1 mutants.
Hum Mol Genet
; 26(11): 2146-2155, 2017 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28379367
14.
Downregulation of the Host Gene jigr1 by miR-92 Is Essential for Neuroblast Self-Renewal in Drosophila.
PLoS Genet
; 11(5): e1005264, 2015 May.
Artigo
Inglês
| MEDLINE | ID: mdl-26000445
15.
Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency.
Hum Mol Genet
; 23(6): 1467-78, 2014 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24163244
16.
TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking.
Acta Neuropathol
; 142(1): 217-221, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-34081168
17.
Inferring the evolutionary history of primate microRNA binding sites: overcoming motif counting biases.
Mol Biol Evol
; 31(7): 1894-901, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-24723422
18.
The FTD/ALS-associated RNA-binding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila.
Hum Mol Genet
; 22(2): 218-25, 2013 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23042786
19.
Lost & found: C9ORF72 and the autophagy pathway in ALS/FTD.
EMBO J
; 35(12): 1251-3, 2016 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27154207
20.
FTD/ALS-associated poly(GR) protein impairs the Notch pathway and is recruited by poly(GA) into cytoplasmic inclusions.
Acta Neuropathol
; 130(4): 525-35, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26031661